Sasidharan's research is primarily focused on characterizing mechanisms that help plants survive climatic stressors. Climate change has increased the incidence of extreme weather events such as drought and flooding dramatically, making crop losses more frequent. Developing crops that can survive these harsh conditions will be of great importance for securing (future) global food supply.

Her research is funded with several grants from the Netherlands Organisation for Scientific Research. She also leads her own research on 'Flooding Stress Biology', is Chair of the research group ‘Plant Stress Resilience’ within the Department of Biology and teaches several courses about the molecular biology of plant adaptive responses to students at Utrecht University.